Sialylated Carbohydrate Antigen (KL-6)

Kit Name	Krebs von den Lungen-6 Detection Kit
Method	Fluorescence dry quantitative immunoassay
Assay Measuring Range	51 U/mL ~ 3,000 U/mL
Incubation Time	10 min
Sample Type	Human serum, Plasma (EDTA), Whole Blood (EDTA)
Reference Range
Storage and Stability	Detection Buffer: Stable for up to 18 months (Store at 2°C–8°C in a sealed, dark environment). Reaction Plate: Stable for up to 18 months (Store sealed at 2°C–30°C).

Order Information

Catalog No.	Product	Test/Kit
FFKL6500C	Krebs von den Lungen-6 Detection Kit	25

Corresponding platform

Learn about the details of the platform corresponding to this reagent

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Introduction

KL-6 (Sialylated Carbohydrate Antigen) is a highly specific, high-molecular-weight glycoprotein predominantly expressed on the surface of alveolar type II epithelial cells. When lung tissue is injured or undergoes chronic inflammation, the alveolar-capillary barrier is compromised, causing KL-6 to be released into the bloodstream at elevated levels.

Clinical Applications

Early Warning & Risk Stratification

Severity Assessment

Prediction of Acute Exacerbations

Treatment Monitoring & Management

Early Warning & Risk Stratification

Serves as a critical biomarker for the early warning of chronic obstructive pulmonary disease (COPD), helping clinicians identify high-risk patients and subclinical lung injury before severe respiratory decline occurs.

Severity Assessment

The concentration of KL-6 in the blood positively correlates with the extent of alveolar damage, providing an objective metric to evaluate the clinical severity of COPD and associated interstitial lung abnormalities.

Prediction of Acute Exacerbations

Elevated KL-6 levels can indicate active epithelial damage and heightened inflammation, assisting physicians in predicting potential acute exacerbations and implementing early interventions.

Treatment Monitoring & Management

Enables dynamic tracking of patient response to therapeutic regimens. Continuous monitoring of KL-6 helps optimize personalized treatment plans and assess the long-term efficacy of respiratory interventions.