Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1)

Kit Name	Soluble FMS-like Tyrosine Kinase-1 Detection Kit
Method	Fluorescence dry quantitative immunoassay
Assay Measuring Range	10 pg/mL ~ 85000 pg/mL
Incubation Time	15 min
Sample Type	Human serum, Plasma (EDTA), Whole Blood (EDTA)
Reference Range	Gestation period \| sFlt-1 (pg/mL) \| PlGF (pg/mL) \| sFlt-1/PlGF ratio ------------------------------------------------------------------------- 10-14 weeks \| 652-2501 \| 28.8-122.0 \| 9.27-54.60 15-19 weeks \| 708-2807 \| 66.2-289.0 \| 3.51-25.70 20-23 weeks \| 572-2997 \| 119.0-605.0 \| 1.82-14.60 24-28 weeks \| 618-3205 \| 169.0-1117.0 \| 0.945-10.00 29-33 weeks \| 773-5165 \| 114.0-1297.0 \| 0.941-33.90 34-36 weeks \| 992-7363 \| 78.0-984.0 \| 1.23-66.40 After 37 weeks \| 1533-9184 \| 54.4-862.0 \| 2.18-112.00
Storage and Stability	18 months at 2°C–30°C.

Order Information

Catalog No.	Product	Test/Kit
FFSFLT1100C	Soluble FMS-like Tyrosine Kinase-1 Detection Kit	25

Corresponding platform

Learn about the details of the platform corresponding to this reagent

Jet-iStar Platform – FIA for Every Healthcare Setting

Introduction

Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) is a tyrosine kinase protein produced by the placenta that acts as a potent anti-angiogenic factor during pregnancy.
It binds to pro-angiogenic proteins (like PLGF) in the bloodstream, preventing them from interacting with their receptors and effectively regulating blood vessel growth.
In pregnancies complicated by preeclampsia, placental stress causes sFlt-1 levels to become abnormally elevated, leading to endothelial dysfunction and maternal hypertension.
Calculating the ratio of sFlt-1 to PLGF is widely recognized as a highly reliable clinical method to predict the onset of preeclampsia weeks before physical symptoms appear.

Clinical Applications

Prediction of preeclampsia

Identification and diagnosis of preeclampsia

Treatment monitoring of preeclampsia