β2-Microglobulin (β2-MG)

Inkcazelo emfutshane:


Iinkcukacha zeMveliso

Iithegi zeMveliso

Iimpawu eziphambili zeMveliso

Ikhithi Igama: βI-2-Microglobulin Ikhithi yokuFumana

Indlela:Fluorescence dry quantitative immunoassay

Uluhlu lovavanyo lovavanyo:

I-Plasma kunye neSerum: 0.40mg/L~20.00mg/L

Umchamo:0.15mg/L~8.00mg/L

Ixesha lokufukamela:Imizuzu eli-10

Skakhulu: Iserum yomntu, iplasma (EDTA anticoagulant), umchamo

Uluhlu lwezalathiso: 

 I-Plasma kunye neSerum: 1.00mg/L ~ 3.00mg/L

Umchamo≤0.30mg/L

UGcino kunye nozinzo:

Isithinteli sokuFumana sizinzile kangangeenyanga ezili-12 ku-2°~8°C.

Isixhobo soVavanyo esitywiniweyo sizinzile kangangeenyanga ezili-12 ku-2°C~30°C. 

Intshayelelo

I-β2-microglobulin (β2-MG) i-globulin encinci ye-molecular eveliswa yi-lymphocytes, iiplatelet kunye ne-polymorphonuclear leukocytes ene-molecular weight ye-11,800.
Yitsheyini ye-β (itsheyini lokukhanya) ye-antigen ye-lymphocyte (HLA) kumphezulu weseli. . Ifumaneka ngokubanzi kumanqanaba aphantsi kakhulu kwi-plasma, umchamo, i-cerebrospinal fluid, i-saliva.
Kubantu abaphilileyo, izinga lokwenziwa kunye nokukhululwa kwe-β2-MG kwi-membrane yeseli zihlala zihlala. I-β2-MG inokuhluzwa ngokukhululekileyo kwi-glomeruli, kwaye i-99.9% ye-β2-MG ehluziweyo iphinda ihlaziywe kwaye ihlaziywe yi-proximal renal tubules.
Kwiimeko apho umsebenzi we-glomerulus okanye i-renal tubule uguqulwa, izinga le-β2-MG egazini okanye umchamo liya kutshintsha.
Inqanaba le-β2-MG kwi-serum lingabonakalisa umsebenzi wokucoca i-glomerulus kwaye ngoko ke inqanaba le-β2-MG kumchamo liyimakishi yokuxilongwa komonakalo we-renal tubules.

Imvumelwano kunye neziKhokelo

ISikhokelo seKDIGO sokuSebenza ngoNyango kwiZifo zeGlomerular (2020)》

Umlinganiselo wokukhutshwa kwe-urinary ye-IgG, i-β-2 microglobulin, iprotheni ebophelelayo ye-retinol, okanye i-α-1 macroglobulin ingaba luncedo lwekliniki kunye ne-prognostic kwizifo ezithile, ezifana ne-Membranous nephropathy kunye ne-Focal segmental glomerulosclerosis.

I-KDIGO Clinical Practice Guideline for Acute Kidney Injury (2012)》

Okokuqala, kungakhathaliseki ukuba ukulimala kwezintso ezibukhali (AKI) zaphuhliswa, zonke izifundo zazinobungqina bokuqala bokungasebenzi kakuhle kwe-tubular kunye noxinzelelo, oluboniswe yi-β2-microglobulinuria yokuqala. 

 

Izicelo zeklinikhi

Uvavanyo lomsebenzi wokucoca iglomerular

Esona sizathu siphambili sokwanda kwe-β2-MG egazini kunye ne-β2-MG eqhelekileyo kumchamo inokuba kukwehla komsebenzi wokuhluza i-glomerular, okuxhaphake kwi-nephritis ebukhali kunye nengapheliyo kunye nokungaphumeleli kwezintso, njl.

Uvavanyo lwe-renal tubular reabsorption

Inqanaba le-β2-MG egazini liyinto eqhelekileyo kodwa ukunyuka komchamo ikakhulu ngenxa yokuphazamiseka ngokucacileyo kwe-renal tubular reabsorption, efumaneka kwi-congenital proximal renal tubules function defect, Fanconi syndrome, i-cadmium engapheliyo, isifo sikaWilson, ukugatywa kwe-renal transplant, njl.

 Ezinye izifo

Amanqanaba aphezulu e-β2-MG asenokubonwa kwimihlaza ebandakanya iiseli ezimhlophe zegazi, kodwa ibaluleke ngakumbi kubantu abasanda kufunyaniswa bene-multiple myeloma. 


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