isiXhosa

β2-Microglobulin (β2-MG)

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Ikhithi Igama: βI-2-Microglobulin Ikhithi yokuFumana

Indlela:Fluorescence dry quantitative immunoassay

Uluhlu lovavanyo lovavanyo:

✭I-Plasma kunye neSerum: 0.40mg/L~20.00mg/L

✭Umchamo:0.15mg/L~8.00mg/L

Ixesha lokufukamela:Imizuzu eli-10

Skakhulu: Iserum yabantu, iplasma (EDTA anticoagulant), umchamo

Uluhlu lwezalathiso: 

✭ I-Plasma kunye neSerum: 1.00mg/L ~ 3.00mg/L

✭Umchamo≤0.30mg/L

UGcino kunye nozinzo:

✭Isithinteli sokuFumana sizinzile kangangeenyanga ezili-12 ku-2°~8°C.

✭Isixhobo soVavanyo esitywiniweyo sizinzile kangangeenyanga ezili-12 ku-2°C～30°C. 

Intshayelelo

•I-β2-microglobulin (β2-MG) i-globulin encinci ye-molecular eveliswa yi-lymphocytes, iiplatelet kunye ne-polymorphonuclear leukocytes ene-molecular weight 11,800.
•Yitsheyini ye-β (itsheyini lokukhanya) ye-antigen ye-lymphocyte (HLA) kumphezulu weseli. . Ifumaneka ngokubanzi kumanqanaba aphantsi kakhulu kwi-plasma, umchamo, i-cerebrospinal fluid, i-saliva.
•Kubantu abaphilileyo, izinga lokwenziwa kunye nokukhululwa kwe-β2-MG kwi-membrane yeseli zihlala zihlala. I-β2-MG inokuhluzwa ngokukhululekileyo kwi-glomeruli, kwaye i-99.9% ye-β2-MG ehluziweyo iphinda ihlaziywe kwaye ihlaziywe yi-proximal renal tubules.
•Kwiimeko apho umsebenzi we-glomerulus okanye i-renal tubule uguqulwa, izinga le-β2-MG egazini okanye umchamo liya kutshintsha.
•Inqanaba le-β2-MG kwi-serum lingabonakalisa umsebenzi wokucoca i-glomerulus kwaye ngoko ke inqanaba le-β2-MG kumchamo ngummakishi wokuxilongwa komonakalo we-renal tubules.

Imvumelwano kunye neziKhokelo

•《ISikhokelo seKDIGO sokuSebenza ngoNyango kwiZifo zeGlomerular (2020)》

Umlinganiselo we-fractional urinary excretion ye-IgG, i-β-2 microglobulin, iprotheni ebophelelayo ye-retinol, okanye i-α-1 macroglobulin ingaba luncedo lwekliniki kunye ne-prognostic kwizifo ezithile, ezifana ne-Membranous nephropathy kunye ne-Focal segmental glomerulosclerosis.

•《I-KDIGO Clinical Practice Guideline for Acute Kidney Injury (2012)》

Okokuqala, kungakhathaliseki ukuba ukulimala kwezintso ezibukhali (AKI) zaphuhliswa, zonke izifundo zazinobungqina bokuqala bokungasebenzi kakuhle kwe-tubular kunye noxinzelelo, oluboniswe yi-β2-microglobulinuria yokuqala. 

 

Izicelo zeklinikhi

•Uvavanyo lomsebenzi wokucoca iglomerular

Esona sizathu siphambili sokwanda kwe-β2-MG egazini kunye ne-β2-MG eqhelekileyo kumchamo inokuba kukwehla komsebenzi wokuhluza i-glomerular, okuxhaphake kwi-nephritis ebukhali kunye nengapheliyo kunye nokungaphumeleli kwezintso, njl.

•Uvavanyo lwe-renal tubular reabsorption

Inqanaba le-β2-MG egazini liyinto eqhelekileyo kodwa ukunyuka komchamo ikakhulu ngenxa yokuphazamiseka ngokucacileyo kwe-renal tubular reabsorption, efumaneka kwi-congenital proximal renal tubules function defect, Fanconi syndrome, i-cadmium engapheliyo, isifo sikaWilson, ukugatywa kwe-renal transplant, njl.

• Ezinye izifo

Amanqanaba aphezulu e-β2-MG asenokubonwa kumhlaza obandakanya iiseli ezimhlophe zegazi, kodwa ibaluleke ngakumbi kubantu abasanda kufunyaniswa bene-myeloma eninzi. 

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