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β2-Microglobulin (β2-MG)

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Tilmaamaha Alaabta Muhiimka ah

Kit Magaca: β2-Qalabka Ogaanshaha Microglobulin

Habka:Fluorescence immunoassay tiro qallalan

Qiyaasta qiyaasta qiyaasta:

✭Plasma iyo Serum: 0.40mg/L~20.00mg/L

✭Kaadi:0.15mg/L~8.00mg/L

Waqtiga soo galitaanka:10 daqiiqo

Sku filan: Serum dadka, balasmaha (EDTA anticoagulant), kaadida

Baaxadda tixraaca: 

✭ Plasma iyo Serum: 1.00mg/L ~ 3.00mg/L

✭Kaadi≤0.30mg/L

Kaydinta iyo Deganaanshaha:

✭Detection Buffer waa mid deggan 12 bilood at 2°~8°C.

✭Aaladda Tijaabadu waxay ku xidhan tahay 12 bilood heerkulka 2°C ~ 30°C. 

Hordhac

•β2-microglobulin (β2-MG) waa unug yar oo globulin ah oo ay soo saaraan lymphocytes, platelets iyo leukocytes polymorphonuclear oo leh miisaan kelli ah 11,800.
•Waa silsiladda β (silsiladda iftiinka) ee antigen-ka lymphocyte antigen (HLA) ee dusha unugyada. . Waxaa si weyn looga helaa heerar aad u hooseeya ee plasma, kaadida, dareeraha cerebrospinal, candhuufta.
•Dadka caafimaadka qaba, heerka isku dhafka iyo sii deynta β2-MG ee xuubka unuggu waa joogto. β2-MG si xor ah ayaa looga sifeyn karaa glomeruli, iyo 99.9% ee β2-MG la sifeeyay ayaa dib loo nuugay oo hoos u dhigay tuubooyinka kelyaha ee u dhow.
•Xaaladaha shaqada glomerulus ama tuubada kelyaha la beddelo, heerka β2-MG ee dhiigga ama kaadida ayaa sidoo kale isbeddeli doona.
•Heerka β2-MG ee serum wuxuu ka tarjumayaa shaqada sifeynta ee glomerulus sidaas darteed heerka β2-MG ee kaadida ayaa calaamad u ah ogaanshaha dhaawaca dhuumaha kelyaha ee u dhow.

Is-afgarad & Tilmaamo

•《Tilmaamaha Dhaqanka Kiliinikada ee KDIGO ee Cudurrada Glomerular (2020)

Cabbirka dheecaanka kaadida ee jajabka ah ee IgG, β-2 microglobulin, borotiinka isku xidha retinol, ama α-1 macroglobulin ayaa laga yaabaa inay lahaadaan kiliinikada iyo utility prognostic cudurada gaarka ah, sida Membranous nephropathy iyo Focal segmental glomerulosclerosis.

•《Tilmaamaha Dhaqanka Kiliinikada ee KDIGO ee Dhaawaca Kelyaha Ba'an (2012)

Marka hore, iyada oo aan loo eegin in dhaawaca kelyaha ee degdega ah (AKI) uu soo baxay, dhammaan maadooyinka waxay lahaayeen caddayn hore oo ah cillad-xumada tuubada iyo walbahaarka, oo ay muujiyeen β2-microglobulinuria hore. 

 

Codsiyada bukaan socodka

•Qiimaynta shaqada sifaynta glomerular

Sababta ugu weyn ee kororka β2-MG ee dhiigga iyo β2-MG caadiga ah ee kaadida waxaa laga yaabaa inay tahay hoos u dhaca shaqada sifeynta glomerular, taas oo caadi ahaan ku dhacda nephritis ba'an iyo dabadheeraad ah iyo cillad kelyaha, iwm.

•Qiimaynta dib u nuugista tuubada kelyaha

Heerka β2-MG ee dhiiga waa mid caadi ah laakiin kororka kaadida waxaa inta badan sabab u ah dib u nuugista tuubada kelyaha ee cad ee daciifka ah, kaas oo laga helo cilladaha shaqada ee tuubooyinka kelyaha ee u dhow, Fanconi syndrome, sumowga cadmium dabadheeraad ah, cudurka Wilson, diidmada xubinta taranka kelyaha, iwm.

• Cudurada kale

Heerarka sare ee β2-MG ayaa sidoo kale laga yaabaa in lagu arko kansarrada ku lug leh unugyada dhiigga cad, laakiin waxay si gaar ah macno ugu leedahay dadka dhowaan laga helay myeloma badan. 

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