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β2-Microglobulin (β2-MG)
Kit Zita: β2-Microglobulin Detection Kit
Nzira:Fluorescence yakaoma quantitative immunoassay
Chiyero chekuyera chiyero:
✭Plasma uye Serum: 0.40mg/L~20.00mg/L
✭Weti: 0.15mg/L~8.00mg/L
Incubation nguva:Maminitsi gumi
Szvakakwana: Serum yevanhu, plasma (EDTA anticoagulant), weti
Reference range:
✭ Plasma uye Serum: 1.00mg/L ~ 3.00mg/L
✭Weti≤0.30mg/L
Kuchengetedza uye Kugadzikana:
✭Detection Buffer yakagadzikana kwemwedzi gumi nemiviri pa2°~8°C.
✭Chidimbu Chekuedza Chishandiso chakagadzikana kwemwedzi gumi nemiviri pa2°C～30°C.
•β2-microglobulin (β2-MG) idiki molecular globulin inogadzirwa ne lymphocytes, platelets uye polymorphonuclear leukocytes ine molecular weight ye 11,800.
•Ndiyo β chain (light chain) yemunhu lymphocyte antigen (HLA) pane cell surface. . Inowanikwa zvakanyanya pamazinga akaderera muplasma, weti, cerebrospinal fluid, mate.
•Muvanhu vane hutano, iyo synthesis rate uye kuburitsa huwandu hwe β2-MG kubva musero membrane inogara iripo. β2-MG inogona kusefa zvakasununguka kubva kune glomeruli, uye 99.9% yekusefa β2-MG inodzokororwa uye yakaderedzwa neproximal renal tubules.
•Mumamiriro ezvinhu apo basa re glomerulus kana renal tubule rinoshandurwa, chiyero che β2-MG muropa kana urini chichachinjawo.
•Chiyero che β2-MG mu serum chinogona kuratidza kusefa kwe glomerulus uye nokudaro chiyero che β2-MG muweti chiratidzo chekuongororwa kweproximal renal tubules kukuvara.
•《KDIGO Clinical Practice Guideline paGlomerular Diseases (2020)》
Chiyero chechikamu chechikamu cheurinary excretion yeIgG, β-2 microglobulin, retinol inosunga mapuroteni, kana α-1 macroglobulin inogona kunge iine kiriniki uye prognostic utility mune chaidzo zvirwere, senge Membranous nephropathy uye Focal segmental glomerulosclerosis.
•《KDIGO Clinical Practice Guideline yeAcute Kidney Injury (2012)》
Kutanga, pasinei nokuti kukuvara kwakanyanya kwetsvo (AKI) kwakagadzirwa, zvidzidzo zvose zvaive neuchapupu hwepakutanga hwekusashanda kwetubula uye kushungurudzika, kunoratidzwa nekutanga β2-microglobulinuria.
•Kuongororwa kwe glomerular filtration basa
Chikonzero chikuru chekuwedzera kwe β2-MG muropa uye yakajairika β2-MG muweti inogona kunge iri kudzikira kweglomerular filtration function, iyo inowanzoitika muacute uye chronic nephritis uye renal kukundikana, nezvimwewo.
•Kuongororwa kwe renal tubular reabsorption
Chiyero che β2-MG muropa chakajairika asi kuwedzera muweti kunonyanya kukonzerwa nekusagadzikana kwerenal tubular reabsorption, iyo inowanikwa mucongenital proximal renal tubules function defect, Fanconi syndrome, chronic cadmium poisoning, Wilson's disease, renal transplant kurambwa, etc.
• Zvimwe zvirwere
Kukwira kwemazinga e-β2-MG kunogona kuonekwawo mugomarara rinosanganisira masero machena eropa, asi zvinonyanya kukosha muvanhu vachangoonekwa vaine myeloma yakawanda.
