Serumu Amyloid A.

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KitName:Joinstar Serum Amyloid Igikoresho cyo Kumenya

Uburyo:fluorescence yumye immunoassay

Suzuma ibipimo byo gupima:5.0mg / L ~ 200.0 mg / L.

Igihe cyo gukuramo:5min

Sbihagije:Serumu yumuntu, plasma (EDTA na Sodium citrate anticoagulant) namaraso yose (EDTA na Sodium citrate anticoagulant)

Urutonde:<10.0mg / L.

Kubika no Guhagarara:

Kumenya Buffer ihagaze amezi 12 kuri 2 ° C ~ 8 ° C.

Igikoresho Ikizamini gifunzeisgihamye amezi 12 kuri 4 ° C.30 ° C.

Intangiriro

Serum amyloide A ikorerwa mu mwijima kandi ikabikwa cyane mu moko. Ikora nka poroteyine ikongora kandi ikingira umubiri, itera ururenda rwa cytokine, chemotaxis ya neutrophile na selile ya mast kandi igahindura ibisubizo byubudahangarwa.

Ni poroteyine ikaze ya chronotropique iri mu cyiciro cya heterogeneous cyumuryango wa apolipoprotein kandi ikaba iboneka mumaraso menshi mumaraso yabantu.

Mubisubizo bikaze mugihe cyo gutwikwa, biterwa na IL-1, IL-6 na TNF, SAA irashobora kuzamurwa inshuro 10-1000 agaciro gasanzwe.

SAA irashobora kuboneka mugihe cya 3-6 h yanduye kandi hamwe nubuzima bucye bwa min 50. Irumva cyane kuruta CRP, kandi guhuza ibi bimenyetso byombi birashobora gutanga itandukaniro ryiza ryokongoka no kwandura.

Mu cyiciro gikaze cyanduye virusi, SAA irazamuka, mubisanzwe igera kuri 10-100 ng / mL. icyakora, mugice gikaze cyubwandu bwa bagiteri, SAA yazamutse cyane kurenza iyanduye virusi, ndetse igera kuri 100-1000mg / L.

Amavuriro

 Amaraso ya biomarker hakiri kare yo gukomeretsa no gutwika

♦ Serum amyloide A (SAA) ni biomarker yamaraso hakiri kare kandi yunvikana kubikomere no gutwika kandi byagaragaye muburwayi bwinshi.

♦ Urwego rwa SAA ruzenguruka mu maraso ruzwiho kwiyongera cyane bitewe no kwangirika kwinyama cyangwa gutwikwa, bikabishyira muri poroteyine ikaze.

Kuzenguruka kwa SAA bishobora kwiyongera inshuro zigera ku 1000 nyuma yo gutwikwa, kwandura, gukomeretsa ingirangingo na nérosose selile no kugabanuka vuba nyuma yo gukira.

Gutandukanya itandukaniro rya bagiteri cyangwa virusi

♦ Urwego rwa SAA ruri hejuru ya 10mg / L ariko munsi ya 100mg / L, byerekana ko kwandura virusi bishoboka.

Urwego rwa SAA ruri hejuru ya 100mg / L rwerekana cyane icyiciro gikaze cyo kwandura bagiteri.

 Gukurikirana imigendekere yindwara zandura

SAA irashobora gukoreshwa nkikintu cyigenga kugirango isuzume ubukana bwa bagiteri, virusi nizindi ndwara zandura no gutwika, mubisanzwe urwego rurenga 500 mg / L rwerekana ikibazo gikomeye.

 Gutahura guhuza SAA na CRP

Urwego rwa SAA ruzamuka mu kwandura virusi na bagiteri kandi rwumva cyane ibitera byoroheje kuruta CRP. Kubwibyo, guhuza SAA na CRP birashobora guha abaganga amakuru menshi.

 Isuzumabumenyi ryerekana ibicanwa

Ihuriro rya SAA rigabanuka vuba nyuma yo gukemura umuriro, bigatuma gupima SAA igikoresho cyingirakamaro mugukurikirana inzira yumuriro kumuntu.


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