β2-Microglobuline (β2-MG)

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Kit Izina: β2-Ibikoresho bya Microglobuline

Uburyo:Fluorescence yumye immunoassay yumye

Suzuma ibipimo byo gupima:

Plasma na Serumu: 0.40mg / L ~ 20.00mg / L.

Inkari: 0.15mg / L ~ 8.00mg / L.

Igihe cyo gukuramo:Iminota 10

Sbihagije: Serumu yumuntu, plasma (EDTA anticoagulant), inkari

Urutonde: 

 Plasma na Serumu: 1.00mg / L ~ 3.00mg / L.

Inkari≤0.30mg / L.

Kubika no Guhagarara:

Kumenya Buffer ihagaze amezi 12 kuri 2 ° ~ 8 ° C.

Igikoresho cyo gupima gifunze neza mumezi 12 kuri 2 ° C ~ 30 ° C. 

Intangiriro

β2-microglobuline (β2-MG) ni globuline ntoya ya globuline ikorwa na lymphocytes, platine na polymorphonuclear leukocytes ifite uburemere bwa 11.800.
Ni β urunigi (urunigi rw'urumuri) rwa lymphocyte antigen (HLA) hejuru ya selile. . Iraboneka cyane kurwego rwo hasi cyane muri plasma, inkari, cerebrospinal fluid, amacandwe.
Mu bantu bazima, igipimo cya synthesis hamwe no kurekura ingano ya β2-MG kuva muri selile ya selile. β2-MG irashobora kuyungurura kubuntu muri glomeruli, naho 99,9% byayungurujwe β2-MG byongeye gusubirwamo no guteshwa agaciro nigituba cyimpyiko zegeranye.
Mubihe aho imikorere ya glomerulus cyangwa impyiko ihindagurika, urwego rwa β2-MG mumaraso cyangwa inkari nabyo bizahinduka.
Urwego rwa β2-MG muri serumu rushobora kwerekana imikorere yo kuyungurura glomerulus bityo urwego rwa β2-MG mu nkari ni ikimenyetso cyo gusuzuma indwara yangirika yimpyiko.

Ubwumvikane & Amabwiriza

Amabwiriza yubuvuzi bwa KDIGO ku ndwara zifata isi (2020)》

Ibipimo byo gusohora inkari zicamo ibice bya IgG, β-2 microglobuline, retinol ihuza poroteyine, cyangwa α-1 macroglobuline irashobora kugira akamaro k’amavuriro na prognostic mu ndwara zihariye, nka Membranous nephropathie na Focal segmental glomerulosclerose.

Amabwiriza y’ubuvuzi ya KDIGO yo gukomeretsa impyiko zikomeye (2012)》

Ubwa mbere, tutitaye ko gukomeretsa gukabije kwimpyiko (AKI) byateje imbere, amasomo yose yari afite ibimenyetso byambere byerekana imikorere mibi yigituba no guhangayika, byerekanwe na β2-microglobulinuria kare. 

 

Amavuriro

Isuzuma ryimikorere ya glomerular

Impamvu nyamukuru yo kwiyongera kwa β2-MG mu maraso hamwe na β2-MG isanzwe mu nkari bishobora kuba igabanuka ryimikorere ya filteri yisi, ikunze kugaragara muri neprite ikaze kandi idakira no kunanirwa kw'impyiko, nibindi.

Isuzuma ryimpyiko tubular reabsorption

Urwego rwa β2-MG mu maraso ni ibisanzwe ariko kwiyongera mu nkari biterwa ahanini n’imyanya ndangagitsina y’impyiko reabsorption igaragara, iboneka mu mikorere y’imyororokere y’imyanya ndangagitsina, syndrome ya Fanconi, uburozi bwa kadmium idakira, indwara ya Wilson, kwanga kwimura impyiko, n'ibindi

 Izindi ndwara

Urwego rwo hejuru rwa β2-MG rushobora no kugaragara muri kanseri irimo selile yera, ariko birasobanutse cyane kubantu baherutse gufatwa na myeloma nyinshi. 


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