Reasonable price Buy Rapid Antigen Test Kit For Covid 19 - Anti-Müllerian Hormone (AMH) – Joinstar

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Reasonable price Buy Rapid Antigen Test Kit For Covid 19 - Anti-Müllerian Hormone (AMH) –JoinstarDetail:

Kit Name: Anti-Müllerian Hormone Detection kit 

Method: Fluorescence dry quantitative immunoassay

Assay measuring range: 0.050ng/mL ~25.000ng/mL

Incubation time: 15 minutes

Sample: Human serum, plasma (EDTA-K2 anticoagulant) and whole blood (EDTA-K2 anticoagulant)

Reference range: 

Gender

age

reference range

female

20-24

1.700ng/mL-9.500ng/mL

(5%CI-95%CI)

25-29

1.150ng/mL-9.100ng/mL

(5%CI-95%CI)

30-34

0.600 ng/mL-7.600ng/mL

(5%CI-95%CI)

35-39

0.800ng/mL-5.300ng/mL

(10%CI-90%CI)

40-44

0.100ng/mL-3.000ng/mL

(10%CI-90%CI)

45-49

0.060ng/mL-2.100ng/mL

(10%CI-90%CI)

Storage and Stability: 

Detection Buffer is stable for 12 months at 2°C ~8°C. 

Sealed Test Device is stable for 12 months at 4°C~30°C.

Anti-Müllerian hormone (AMH) is a glycoprotein, a dimer consisting of two identical 72 kDa monomers linked by a disulfide bond. It belongs to the transforming growth factor-β family.

AMH is differentially expressed at different stages of male and female growth and development, and there are differences in its biological roles.

During embryonic development, AMH regulates the differentiation and development of the reproductive ducts and is essential for sex differentiation. After birth, AMH regulates the function of male testicular mesenchymal cells.

In adult females, AMH inhibits the recruitment of primordial follicles and the development of antral follicles, preventing premature follicular depletion.

AMH reflects the age-related decline in ovarian reserve earlier than follicle stimulating hormone (FSH), estradiol (E2), inhibin B (inhB) and antral follicle count (AFC), and its levels are not affected by the menstrual cycle, hormonal contraceptives, or pregnancy.

Practice Committee of the American Society for Reproductive MedicinePrevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline(2016)》

There is fair evidence (level II-2) that PCOS, elevated AMH values, peak estradiol levels, multifollicular development, and a high number of oocytes retrieved are associated with an increased risk of ovarian hyperstimulation syndrome (OHSS). (Grade B)

American College of Obstetricians and Gynecologists (ACOG)Committee opinion no. 618: Ovarian reserve testing(2015)》 

For general obstetrician–gynecologists, the most appropriate ovarian reserve screening tests to use in practice are basal FSH plus estradiol levels or AMH levels.

Practice Committee of the American Society for Reproductive MedicineTesting and interpreting measures of ovarian reserve: a committee opinion(2015)》

Overall, FSH is the most commonly used screening test for decreased ovarian reserve (DOR), but AFC and AMH exhibit less variability and therefore are promising predictors.

National Institute for Health and Care Excellence (NICE) 《Fertility problems: assessment and treatment Clinical guideline (2013)》

Anti-Müllerian hormone of less than or equal to 5.4 pmol/l for a low response and greater than or equal to 25.0 pmol/l for a high response.

ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria (2011)》

Several reviews analysed the predictive value of single and combined tests performed in basal conditions. Of all the tests, AFC and AMH had the best sensitivity and specificity for predicting ovarian response.

Assessment of ovarian reserve function 

AMH is a sensitive and specific marker for evaluating ovarian reserve function.

Diagnosis of premature ovarian failure (POF)

The level of AMH is reduced in patients with hypoovarianism, and it is almost undetectable in patients with POF.

Diagnosis of polycystic ovary syndrome (PCOS)

The level of AMH in patients with PCOS is 2-3 times higher than normal.

Diagnosis and monitoring of ovarian granulosa cell tumour (GCT)

It is significantly elevated in patients with GCT and is used for follow-up monitoring of GCT treatment.

Prediction of ovarian responsiveness in assisted reproductive technology (ART)

It can be used to predict ovarian hypo responsiveness and ovarian hyperstimulation to develop individualised stimulation protocols for improving pregnancy rates to some extent and preventing complications.

asdada

Figure 1. AMH is secreted by pre-antral and antral follicles.


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