Procalcitonin

Short Description:


Product Detail

Product Tags

Key Product Characteristics

Kit Name : Joinstar Procalcitonin Detection Kit

Method: fluorescence dry quantitative immunoassay

Assay measuring range: 0.10ng/mL ~ 100.00ng/mL

Incubation time: 12min

Sample: human serum, plasma  (EDTA anticoagulant、trisodium citrate), whole blood (EDTA anticoagulant、trisodium citrate)

Reference range: <0.50ng/mL

Storage and Stability: 

Detection Buffer is stable for 12 months at 2°C ~8°C.

Sealed Test Device is stable for 12 months at 4°C~30°C. 

Introduction

Procalcitonin (PCT) is the 116 amino acid precursor of the hormone calcitonin, produced by the C cells of the thyroid. Its synthesis is upregulated in bacterial infection.

It is detectable within 2–4 h of infection, peaks within 6–24 h and can be present for up to 7 days.

It has been proposed as a useful biomarker of bacterial infection and its use is related to reduced duration of antibiotic therapy.

PCT is regarded as an early marker of sepsis in different settings, including ED, regular wards, surgical wards and ICU.

ICU

Consensus & Guidelines

Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock(2021)》

In a meta-analysis of 30 studies (3,244 patients), procalcitonin had a pooled sensitivity of 77% and specificity of 79% for sepsis in critically ill patients.

The guidelines propose  using procalcitonin and clinical based judgements  to decide when to discontinue antimicrobials over clinical evaluation alone.

Clinical Applications

Diagnosis of sepsis

As PCT levels are highly specific for sepsis caused by bacterial infection, PCT can be used as the biomarker to diagnose sepsis (at a cut-off of >2ng/mL) and differentiate severe bacterial infection.

Assess the severity and progression of sepsis

It has been shown that increasing levels of PCT > (> 2 ng/mL) or  are associated with increased disease severity  Therefore PCT may be used to monitor disease progression.

Sepsis prognosis

A rapid decline in PCT after treatment is usually associated with a favorable prognosis, whereas no reduction in PCT levels suggest a poor prognosis.

PCT guided use of antibiotic therapy

As an indicator of when to start antibiotic treatment.

As a marker to judge the efficacy of antibiotics.


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