Procalcitonin

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Product Detail

Product Tags

Key Product Characteristics

Kit Name : Joinstar Procalcitonin Detection Kit

Method: fluorescence dry quantitative immunoassay

Assay measuring range: 0.10ng/mL ~ 100.00ng/mL

Incubation time: 12min

Sample: human serum, plasma  (EDTA anticoagulant、trisodium citrate), whole blood (EDTA anticoagulant、trisodium citrate)

Reference range: <0.50ng/mL

Storage and Stability: 

Detection Buffer is stable for 12 months at 2°C ~8°C. 

Sealed Test Device is stable for 12 months at 4°C~30°C.

Introduction

• Procalcitonin (PCT) is the 116 amino acid precursor of the hormone calcitonin, produced by the C cells of the thyroid. Its synthesis is upregulated in bacterial infection.

• It is detectable within 2–4 h of infection, peaks within 6–24 h and can be present for up to 7 days.

• It has been proposed as a useful biomarker of bacterial infection and its use is related to reduced duration of antibiotic therapy.

• PCT is regarded as an early marker of sepsis in different settings, including ED, regular wards, surgical wards and ICU.

ICU

Consensus & Guidelines

《Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock(2021)》

♦ In a meta-analysis of 30 studies (3,244 patients), procalcitonin had a pooled sensitivity of 77% and specificity of 79% for sepsis in critically ill patients.

♦ The guidelines propose  using procalcitonin and clinical based judgements  to decide when to discontinue antimicrobials over clinical evaluation alone.

Clinical Applications

● Diagnosis of sepsis

As PCT levels are highly specific for sepsis caused by bacterial infection, PCT can be used as the biomarker to diagnose sepsis (at a cut-off of >2ng/mL) and differentiate severe bacterial infection.

● Assess the severity and progression of sepsis

It has been shown that increasing levels of PCT > (> 2 ng/mL) or  are associated with increased disease severity  Therefore PCT may be used to monitor disease progression.

● Sepsis prognosis

A rapid decline in PCT after treatment is usually associated with a favorable prognosis, whereas no reduction in PCT levels suggest a poor prognosis.

● PCT guided use of antibiotic therapy

♦ As an indicator of when to start antibiotic treatment.

♦ As a marker to judge the efficacy of antibiotics.


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