β2-Microglobulin (β2-MG)

Kufotokozera Kwachidule:


Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Makhalidwe Ofunika Kwambiri

Zida Dzina: β2-Microglobulin Detection Kit

Njira:Fluorescence dry quantitative immunoassay

Mlingo woyezera:

Plasma ndi Seramu: 0.40mg/L~20.00mg/L

Mkodzo: 0.15mg/L~8.00mg/L

Nthawi ya incubation:Mphindi 10

Szokwanira: Seramu yamunthu, plasma (EDTA anticoagulant), mkodzo

Masanjidwe ake: 

 Plasma ndi Seramu: 1.00mg/L~3.00mg/L

Mkodzo≤0.30mg/L

Kusunga ndi Kukhazikika:

Kuzindikira Buffer kumakhala kokhazikika kwa miyezi 12 pa 2°~8°C.

Chipangizo Choyesera Chosindikizidwa chimakhala chokhazikika kwa miyezi 12 pa 2°C~30°C. 

Mawu Oyamba

β2-microglobulin (β2-MG) ndi globulin yaing'ono ya molekyulu yopangidwa ndi ma lymphocytes, mapulateleti ndi polymorphonuclear leukocytes ndi molekyulu yolemera 11,800.
Ndi tcheni cha β (chowala) cha antigen lymphocyte (HLA) pa cell. . Amapezeka kwambiri pamilingo yotsika kwambiri mu plasma, mkodzo, cerebrospinal fluid, malovu.
Mwa anthu athanzi, kuchuluka kwa kaphatikizidwe ndi kuchuluka kwa β2-MG kuchokera ku cell membrane kumakhala kosasintha. β2-MG imatha kusefedwa momasuka kuchokera ku glomeruli, ndipo 99.9% ya β2-MG yosefedwa imalowetsedwanso ndikuwonongeka ndi proximal tubules aimpso.
M'mikhalidwe yomwe ntchito ya glomerulus kapena aimpso tubule imasinthidwa, mulingo wa β2-MG m'magazi kapena mkodzo udzasinthanso.
Mulingo wa β2-MG mu seramu ukhoza kuwonetsa kusefera kwa glomerulus motero mulingo wa β2-MG mumkodzo ndi chizindikiro chodziwikiratu kuwonongeka kwa ma proximal tubules aimpso.

Kugwirizana & Malangizo

KDIGO Clinical Practice Guideline on Glomerular Diseases (2020)》

Kuyeza kwa kutulutsa kwamkodzo kwa IgG, β-2 microglobulin, mapuloteni omangira retinol, kapena α-1 macroglobulin zitha kukhala zothandiza pazachipatala komanso zodziwika bwino pa matenda enaake, monga Membranous nephropathy ndi Focal segmental glomerulosclerosis.

KDIGO Clinical Practice Guideline for Acute Kidney Injury (2012)》

Choyamba, mosasamala kanthu kuti kuvulala koopsa kwa impso (AKI) kunayamba, maphunziro onse anali ndi umboni woyambirira wa kusagwira ntchito kwa tubular ndi kupsinjika maganizo, zosonyezedwa ndi β2-microglobulinuria oyambirira. 

 

Ntchito Zachipatala

Kuwunika ntchito ya kusefera kwa glomerular

Chifukwa chachikulu chakuchulukira kwa β2-MG m'magazi ndi β2-MG wamba mumkodzo kungakhale kuchepa kwa kusefera kwa glomerular, komwe nthawi zambiri kumakhala pachimake komanso chosatha komanso kulephera kwaimpso, ndi zina zotero.

Kuwunika kwa aimpso tubular reabsorption

Mlingo wa β2-MG m'magazi ndi wabwinobwino, koma kuchuluka kwa mkodzo kumachitika makamaka chifukwa cha kuwonongeka kwa aimpso, komwe kumapezeka mu congenital proximal renal tubules function, Fanconi syndrome, poisoning cadmium, matenda a Wilson, kukana kuyika aimpso, ndi zina.

 Matenda ena

Miyezo yokwera ya β2-MG imatha kuwonekanso m'makhansa okhudzana ndi maselo oyera amagazi, koma ndizofunikira kwambiri mwa anthu omwe angowapeza kumene ali ndi myeloma yambiri. 


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