Interleukin 6

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Product Detail

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Key Product Characteristics

Kit Name: Joinstar Interleukin-6 Detection Kit

Method: fluorescence dry quantitative immunoassay

Assay measuring range: 3.0pg/mL~5000.0pg/mL

Incubation time: 18min

Sample: human serum, plasma (EDTA anticoagulant and Sodium citrate anticoagulant), whole blood (EDTA anticoagulant and Sodium citrate anticoagulant)

Reference range: ≤7.0pg/mL

Storage and Stability: 

Detection Buffer is stable for 12 months at 2°C ~8°C. 

Sealed Test Device is stable for 12 months at 4°C~30°C.

Introduction

 Interleukin 6 (IL-6) is an inflammatory factor consisting of 184 amino acid residues with a relative molecular weight of 26 KDa.

 IL-6 is mainly secreted by monocytes, macrophages, B cells, T cells, endothelial cells and fibroblasts, and exerts its biological effects by binding to its receptors.

 IL-6 rises rapidly after infection, peaking at 2h with a half-life of only 1h.

 It stimulates the synthesis of CRP and SAA in hepatocytes and induces the production of PCT.

 IL-6 can be used to aid in the management of critically ill patients as early indicator for acute inflammation.

 The concentration of IL-6 is also significantly increased in autoimmune diseases, acute pancreatitis, cardiovascular diseases, tumors, burns, trauma, etc. 

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Fig. 1.   Kinetics of various markers of the inflammatory host response after endotoxin challenge in human volunteers .CRP, C-reactive protein; IL, interleukin; PCT, procalcitonin; TNF, tumor necrosis factor.

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Fig. 2  IL-6-producing cells and biological activities of IL-6.

Consensus & Guidelines

《The Chinese expert consensus on interpretation of clinical significance of infection-related biomarkers》

♦ In the inflammatory response, IL-6 is elevated earlier than other cytokines, as well as CRP and PCT, and has a longer duration, so it can be used to assist in the early diagnosis of acute infection.

♦ IL-6 levels > 1000ug/L indicates poor prognosis.

The Chinese protocol for the treatment of heavy and critically ill cases of COVID-19 (Trial Version 2)

For critically ill patients, a progressive increase in peripheral blood inflammatory factors such as IL-6 and CRP is one of the references that should alert to the deterioration of the disease. 

Clinical Applications

• Early diagnosis of acute infection

IL-6 is central to the inflammatory cascade response and is elevated earlier and with greater sensitivity than CRP and PCT in the early stages of infection.

 Severity of infection assessment

The elevated level of IL-6 corresponds to the severity of the infection, and it can be used to evaluate the severity of the infection.

 Diagnosis of sepsis

The specificity of IL-6 is slightly lower than that of PCT, so the combined testing of multiple infection markers can complement each other and have higher diagnostic value.

 Warning of sepsis

IL-6 is a marker for early warning of sepsis and its levels correlate significantly with APACHE II and SOFA scores.

 Guidance on the use of antibiotics

The short half-life of IL-6 is very useful for insufficient PCT, which can provide a quicker indication of the effectiveness of antibiotic treatment in the early stages of infection.


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