β2-Microglobulin (β2-MG)

Nkọwa dị mkpirikpi:


Nkọwa ngwaahịa

Mkpado ngwaahịa

Njirimara ngwaahịa igodo

Kit Aha: β2- Ngwa nchọpụta microglobulin

Usoro:Fluorescence akọrọ quantitative immunoassay

Oke nlele nyocha:

Plasma na ọbara: 0.40mg/L~20.00mg/L

Urine: 0.15mg/L ~ 8.00mg/L

Oge nnabata:Nkeji 10

Szuru oke:Ọbara mmadụ, plasma (EDTA anticoagulant), mmamịrị

Oke ntụaka: 

Plasma na ọbara: 1.00mg/L ~ 3.00mg/L

Urine≤0.30mg/L

Nchekwa na kwụsie ike:

Nchekwa nchọpụta kwụsiri ike maka ọnwa 12 na 2°~8°C.

Ngwa ule emechiri emechi kwụsiri ike maka ọnwa 12 na 2°C ~ 30°C.

Okwu mmalite

β2-microglobulin (β2-MG) bụ obere molekụla globulin mepụtara site na lymphocytes, platelet na leukocytes polymorphonuclear nwere ibu molekụla nke 11,800.
Ọ bụ yinye β (agbụ ọkụ) nke antigen lymphocyte mmadụ (HLA) n'elu cell. . A na-ahụ ya n'ọtụtụ ebe na ọkwa dị ala na plasma, mmamịrị, mmiri cerebrospinal, mmiri mmiri.
N'ime ndị nwere ahụike, ọnụọgụ njikọ na ntọhapụ nke β2-MG sitere na akpụkpọ ahụ cell na-adịgide adịgide. Enwere ike ịchacha β2-MG n'efu site na glomeruli, na 99.9% nke β2-MG akọrọ na-eweghachi ma mebie ya site na tubules gbasara akụrụ dị nso.
N'ọnọdụ ebe a gbanwere ọrụ glomerulus ma ọ bụ tubule gbasara akụrụ, ọkwa β2-MG n'ọbara ma ọ bụ mmamịrị ga-agbanwekwa.
Ọkwa β2-MG na serum nwere ike igosipụta ọrụ nzacha nke glomerulus ma yabụ ọkwa nke β2-MG na mmamịrị bụ akara maka nchọpụta nke mmebi akụrụ na-esote.

Nkwekọrịta & Ntuziaka

Ntuziaka Omume Clinical KDIGO na Ọrịa Glomerular (2020)

Ntụle nke mpụ nke mmamịrị nke irighiri nke IgG, β-2 microglobulin, protein protein na-ejikọta retinol, ma ọ bụ α-1 macroglobulin nwere ike ịnwe uru ahụike na prognostic na ọrịa ndị akọwapụtara, dị ka Membranous nephropathy na Focal segmental glomerulosclerosis.

Ntuziaka Omume Clinical KDIGO maka mmerụ ahụ akụrụ dị ukwuu (2012)》

Nke mbụ, n'agbanyeghị ma nnukwu mmerụ ahụ akụrụ (AKI) mepụtara, isiokwu niile nwere ihe ngosi mmalite nke nkwụsịtụ tubular na nrụgide, nke β2-microglobulinuria na-egosi n'oge.

 

Ngwa ụlọ ọgwụ

Ntụle ọrụ nzacha glomerular

Isi ihe kpatara mmụba nke β2-MG na ọbara yana β2-MG nkịtị na mmamịrị nwere ike ịbụ mbelata ọrụ filtration glomerular, nke na-adịkarị na nephritis na-adịghị ala ala na ọdịda akụrụ, wdg.

Ntụle nke renal tubular reabsorption

Ọkwa β2-MG n'ọbara bụ ihe nkịtị mana mmụba na mmamịrị bụ ọkachasị n'ihi mgbake renal tubular reabsorption doro anya, nke a na-ahụta na ntụpọ arụrụ arụ ọrụ renal proximal, Fanconi syndrome, nsi cadmium na-adịghị ala ala, ọrịa Wilson, ntugharị akụrụ, wdg.

 Ọrịa ndị ọzọ

Enwere ike ịhụ ọkwa dị elu nke β2-MG na ọrịa kansa ndị metụtara mkpụrụ ndụ ọbara ọcha, mana ọ bara uru karịsịa na ndị mmadụ achọpụtara ọhụrụ nwere multiple myeloma.


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