β2-Microglobulin (β2-MG)

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Product Detail

Khoom cim npe

Cov yam ntxwv tseem ceeb ntawm cov khoom

Kit Lub npe: β2-Microglobulin Detection Kit

Txoj kev:Fluorescence qhuav quantitative immunoassay

Kev ntsuas ntsuas ntau:

Plasma thiab Serum: 0.40mg / L ~ 20.00mg / L

Cov zis: 0.15mg / L ~ 8.00mg / L

Lub sijhawm incubation:10 feeb

Stxaus: Tib neeg cov ntshav plasma (EDTA anticoagulant), tso zis

Kev siv ntau yam: 

 Plasma thiab Serum: 1.00mg / L ~ 3.00mg / L

Cov zis ≤0.30mg / L

Cia thiab Stability:

Kev kuaj pom tsis pom kev ruaj khov rau 12 lub hlis ntawm 2 ° ~ 8 ° C.

Cov Khoom Siv Hluav Taws Xob kaw ruaj khov rau 12 lub hlis ntawm 2 ° C ~ 30 ° C. 

Taw qhia

β2-microglobulin (β2-MG) yog ib qho me me molecular globulin tsim los ntawm lymphocytes, platelets thiab polymorphonuclear leukocytes nrog ib qho hnyav molecular ntawm 11,800.
Nws yog β saw (lub teeb saw) ntawm tib neeg lymphocyte antigen (HLA) ntawm lub xov tooj ntawm tes. . Nws yog dav pom nyob rau hauv cov ntshav plasma, zis, cerebrospinal kua, qaub ncaug.
Hauv cov neeg noj qab haus huv, qhov sib xyaw ua ke thiab tso tawm ntawm β2-MG los ntawm cov cell membrane yog tas li. β2-MG tuaj yeem lim tau dawb los ntawm lub glomeruli, thiab 99.9% ntawm cov lim dej β2-MG yog reabsorbed thiab degraded los ntawm proximal raum tubules.
Hauv cov xwm txheej uas qhov kev ua haujlwm ntawm glomerulus lossis lub raum tubule hloov pauv, qib ntawm β2-MG hauv cov ntshav lossis zis kuj tseem yuav hloov.
Qib ntawm β2-MG hauv cov ntshav tuaj yeem cuam tshuam qhov pom kev ua haujlwm ntawm glomerulus thiab yog li qib ntawm β2-MG hauv cov zis yog ib qho cim rau kev kuaj mob ntawm lub raum raum kev puas tsuaj.

Kev pom zoo & Cov Lus Qhia

KDIGO Clinical Practice Guideline on Glomerular Diseases (2020) 》

Kev ntsuas ntawm fractional urinary excretion ntawm IgG, β-2 microglobulin, retinol binding protein, los yog α-1 macroglobulin tej zaum yuav muaj kev kho mob thiab prognostic utility nyob rau hauv tej yam kab mob, xws li Membranous nephropathy thiab Focal segmental glomerulosclerosis.

KDIGO Clinical Practice Guideline for Acute Kidney Injury (2012) 》

Ua ntej, tsis hais seb puas mob raum raug mob (AKI) tsim, txhua yam kev kawm tau muaj pov thawj ntxov ntawm tubular tsis ua haujlwm thiab kev ntxhov siab, qhia los ntawm β2-microglobulinuria thaum ntxov. 

 

Kev siv tshuaj kho mob

Kev soj ntsuam ntawm glomerular filtration muaj nuj nqi

Qhov laj thawj tseem ceeb ntawm kev nce ntawm β2-MG hauv cov ntshav thiab qhov qub β2-MG hauv cov zis yuav yog qhov txo qis ntawm glomerular filtration function, uas feem ntau yog mob nephritis thiab lub raum tsis ua haujlwm, thiab lwm yam.

Kev ntsuam xyuas ntawm lub raum tubular reabsorption

Cov theem ntawm β2-MG hauv cov ntshav yog ib txwm tab sis nce hauv cov zis yog vim qhov pom tseeb ntawm lub raum tsis ua haujlwm ntawm lub raum tubular reabsorption, uas pom muaj nyob rau hauv congenital proximal renal tubules function defect, Fanconi syndrome, chronic cadmium poisoning, Wilson's disease, renal transplant rejection, lwm.

 Lwm yam kab mob

Kev nce qib ntawm β2-MG kuj tseem tuaj yeem pom hauv cov qog nqaij hlav uas muaj cov qe ntshav dawb, tab sis nws muaj txiaj ntsig tshwj xeeb rau cov neeg uas tau kuaj pom ntau yam myeloma. 


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