β2-Microglobulin (β2-MG)

ʻO ka wehewehe pōkole:


Huahana Huahana

Huahana Huahana

Nā ʻano huahana koʻikoʻi

Kit inoa: β2-Pahu ʻImi Microglobulin

Hanana:Fluorescence maloʻo quantitative immunoassay

Laulā ana ana:

Plasma a me Serum: 0.40mg/L~20.00mg/L

Mimi:0.15mg/L~8.00mg/L

Ka manawa incubation:10 minuke

Snui: Ke koko kanaka, plasma (EDTA anticoagulant), mimi

Laulā kuhikuhi: 

 Plasma a me Serum: 1.00mg/L~3.00mg/L

Mimi≤0.30mg/L

Ka mālama a me ka paʻa:

Paʻa ka Detection Buffer no 12 mahina ma 2°~8°C.

Paʻa ka mea hoʻāʻo i hoʻopaʻa ʻia no 12 mahina ma 2°C~30°C. 

Hoʻolauna

ʻO ka β2-microglobulin (β2-MG) he globulin liʻiliʻi liʻiliʻi i hana ʻia e nā lymphocytes, platelets a me nā leukocytes polymorphonuclear me ke kaumaha molekala o 11,800.
ʻO ia ke kaulahao β (ke kaulahao māmā) o ke kanaka lymphocyte antigen (HLA) ma ka ʻili pūnaewele. . Loaʻa nui ia ma nā pae haʻahaʻa loa i ka plasma, mimi, ka wai cerebrospinal, saliva.
I nā kānaka olakino, mau ka helu synthesis a me ka nui o ka hoʻokuʻu ʻana o β2-MG mai ka membrane cell. Hiki ke kānana manuahi ka β2-MG mai ka glomeruli, a ʻo 99.9% o ka β2-MG i kānana ʻia e hoʻihoʻi ʻia a hoʻohaʻahaʻa ʻia e nā tubules renal proximal.
I nā kūlana kahi i hoʻololi ʻia ai ka hana o ka glomerulus a i ʻole ka renal tubule, e loli pū ka pae o β2-MG i ke koko a i ʻole ka mimi.
Hiki i ke kiʻekiʻe o β2-MG i loko o ka serum ke hōʻike i ka hana kānana o glomerulus a no laila ke kiʻekiʻe o ka β2-MG i loko o ka mimi he hōʻailona no ka hōʻailona o ka pōʻino o nā tubules renal proximal.

Kuʻikahi & alakaʻi

KDIGO Ke alakaʻi hoʻomaʻamaʻa lapaʻau no nā maʻi Glomerular(2020)》

ʻO ke ana o ka fractional urinary excretion o IgG, β-2 microglobulin, retinol binding protein, a i ʻole α-1 macroglobulin hiki ke loaʻa i nā pono lapaʻau a me ka prognostic i nā maʻi kūikawā, e like me Membranous nephropathy a me Focal segmental glomerulosclerosis.

KDIGO Ke alakaʻi hoʻomaʻamaʻa maʻi no ka ʻeha ʻeha ʻeha (2012)》

ʻO ka mea mua, me ka nānā ʻole i ka ulu ʻana o ka hōʻeha ʻeha ʻeha (AKI), ua loaʻa i nā kumuhana āpau nā hōʻike mua o ka tubular dysfunction a me ke kaumaha, i hōʻike ʻia e ka β2-microglobulinuria mua. 

 

Nā noi lāʻau lapaʻau

Ka loiloi o ka hana kānana glomerular

ʻO ke kumu nui o ka hoʻonui ʻana i ka β2-MG i loko o ke koko a me ka β2-MG maʻamau i ka mimi ʻo ia ka emi ʻana o ka hana kānana glomerular, ʻo ia ka mea maʻamau i ka nephritis acute a me ka maʻi a me ka hana ʻole o ka renal, etc.

Ka loiloi o ka renal tubular reabsorption

ʻO ke kiʻekiʻe o ka β2-MG i loko o ke koko he mea maʻamau akā ʻo ka piʻi ʻana o ka mimi ma muli o ka renal tubular reabsorption i ʻike ʻia, i loaʻa i ka congenital proximal renal tubules function defect, Fanconi syndrome, maʻi cadmium maʻi, maʻi Wilson, hōʻole i ka renal transplant, etc.

 ʻO nā maʻi ʻē aʻe

Hiki ke ʻike ʻia nā kiʻekiʻe kiʻekiʻe o β2-MG i nā maʻi maʻi e pili ana i nā keʻokeʻo keʻokeʻo, akā he mea koʻikoʻi ia i nā poʻe i ʻike hou ʻia me ka mieloma lehulehu. 


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