β2-Microglobulin (β2-MG)

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Tags samfurin

Mabuɗin Halayen Samfur

Kit Suna: β2-Kit ɗin Gano Microglobulin

Hanya:Fluorescence bushe ƙididdige immunoassay

Ma'aunin aunawa:

Plasma da Magani: 0.40mg/L~20.00mg/L

Fitsari:0.15mg/L~8.00mg/L

Lokacin ƙaddamarwa:Minti 10

Swadatacce: Serum na mutum, plasma (EDTA anticoagulant), fitsari

Kewayon nuni: 

 Plasma da Magani: 1.00mg/L ~ 3.00mg/L

Fitsari ≤0.30mg/L

Ajiya da Kwanciyar hankali:

Buffer Ganewa ya tsaya tsayin daka na tsawon watanni 12 a 2° ~ 8°C.

Na'urar Gwajin da aka rufe ta tsaya tsayin daka na tsawon watanni 12 a 2°C ~ 30°C. 

Gabatarwa

β2-microglobulin (β2-MG) ƙaramin globulin ne na kwayoyin halitta wanda lymphocytes, platelets da polymorphonuclear leukocytes ke samarwa tare da nauyin kwayoyin halitta na 11,800.
Ita ce sarkar β (sarkar haske) na antigen lymphocyte na mutum (HLA) akan saman tantanin halitta. . Ana samun shi sosai a ƙananan matakan jini, fitsari, ruwan cerebrospinal, miya.
A cikin mutane masu lafiya, adadin kira da adadin sakin β2-MG daga membrane cell suna dawwama. Ana iya tace β2-MG kyauta daga glomeruli, kuma 99.9% na tace β2-MG ana sake dawo da su kuma an lalata su ta hanyar tubules na renal na kusa.
A cikin yanayin da aikin glomerulus ko renal tubule ya canza, matakin β2-MG a cikin jini ko fitsari shima zai canza.
Matsayin β2-MG a cikin jini zai iya nuna aikin tacewa na glomerulus kuma don haka matakin β2-MG a cikin fitsari alama ce ta ganewar cututtukan cututtukan ƙwayar cuta na kusanci.

Ijma'i & Jagorori

KDIGO Jagoran Ayyuka na Clinical akan Cututtukan Glomerular (2020)

Ma'auni na ƙayyadaddun ƙwayar fitsari na IgG, β-2 microglobulin, furotin mai ɗaure retinol, ko α-1 macroglobulin na iya samun aikin asibiti da tsinkaye a cikin takamaiman cututtuka, kamar Membranous nephropathy da Focal segmental glomerulosclerosis.

KDIGO Jagoran Ayyuka na Clinical don Rauni mai Ciwon Koda (2012)》

Na farko, ba tare da la'akari da ko raunin koda mai tsanani (AKI) ya ci gaba ba, duk batutuwa sun sami shaidar farko na rashin aiki na tubular da damuwa, wanda aka nuna ta farkon β2-microglobulinuria. 

 

Aikace-aikace na asibiti

Kimanta aikin tacewa na glomerular

Babban dalilin karuwar β2-MG a cikin jini da β2-MG na yau da kullun a cikin fitsari na iya zama raguwar aikin tacewa na glomerular, wanda galibi a cikin matsanancin nephritis da na kullum da gazawar koda, da sauransu.

Kimantawa na renal tubular reabsorption

Matsayin β2-MG a cikin jini na al'ada ne amma yana ƙaruwa a cikin fitsari galibi saboda rashin ƙarfi na renal tubular reabsorption, wanda aka samo a cikin lahani na aikin renal proximal na renal, cututtukan Fanconi, guba na cadmium na yau da kullun, cutar Wilson, ƙin dasawa na koda, da dai sauransu.

 Sauran cututtuka

Hakanan ana iya ganin manyan matakan β2-MG a cikin cututtukan daji da suka haɗa da fararen jini, amma yana da ma'ana musamman a cikin mutanen da aka kamu da cutar myeloma da yawa. 


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