C-Reactive Protein

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Product Detail

Product Tags

Key Product Characteristics

Kit Name: Joinstar Whole Course C-Reactive Protein Detection Kit

Method: fluorescence dry quantitative immunoassay

Assay measuring range: 0.5mg/L ~ 200mg/L

Incubation time: 3min

Sample: human serum, plasma (EDTA anticoagulant), whole blood (EDTA anticoagulant)

Reference range: hsCRP for cardiovascular disease < 1mg/L;

CRP for inflammatory disease <10mg/L

Storage and Stability:

✭Detection Buffer is stable for 12 months at 2°C ~8°C.

✭Sealed Test Device is stable for 12 months at 4°C～30°C.

Introduction

• C-reactive protein (CRP) is a pentamer composed of five identical subunits bound in a non-covalent form and is one of the acute phase proteins synthesized by hepatocytes.

• The level of CRP often increases 6-12 h after the initial onset of the infection or inflammation and reaches a peak in 24-48 h. The level of increase in CRP is positively correlated with disease severity .

• In healthy individuals, the levels of CRP are usually low (<10 mg/L) whilst they increase in the presence of inflammatory disease, tissue damage, malignancy, surgical trauma, or coronary artery disease.

• Hypersensitive C-reactive protein (hsCRP) can be used to assess the risk of cardiovascular disease. hsCRP <1.0 mg/L is considered low risk, 1.0-3.0 mg/L is considered moderate risk, and >3.0 mg/L is considered high risk.

Consensus & Guidelines

• 《Guidelines for the management of adult lower respiratory tract infections--full version》

In patients with suspected pneumonia, CRP levels of <20 mg/L at presentation, and with symptoms for >24 h, the presence of pneumonia is highly unlikely, whilst alevel of >100 mg/L makes pneumonia likely.

Clinical Applications

• Differential diagnosis of infectious diseases

CRP is a sensitive but nonspecific biomarker of bacterial infection. It is generally regarded as a more sensitive test than erythrocyte sedimentation rate（ESR）or white blood cell count（WBC）.

• Evaluation the effectiveness of antibiotic therapy

CRP is often used to evaluate the efficacy of antibiotics as it can respond to the changes during inflammation or infection.

• Monitoring of postoperative infections

CRP can be used in the monitoring of serious surgical infections and postoperative complications.

• Risk prediction for cardiovascular disease

hsCRP is an excellent biomarker of cardiovascular disease and as well as an independent and strong predictor of adverse cardiovascular events.

• Other diseases

CRP is also used in the diagnosis and management of inflammatory diseases, such as Rheumatoid arthritis or Lupus, as levels go up in such conditions.

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