β2-Microglobulin (β2-MG)

Short Description:


Product Detail

Product Tags

Key Product Characteristics

Kit Name: β2-Microglobulin Detection Kit

Method: Fluorescence dry quantitative immunoassay

Assay measuring range:

Plasma and Serum: 0.40mg/L~20.00mg/L

Urine:0.15mg/L~8.00mg/L

Incubation time: 10 minutes

Sample: Human serum, plasma (EDTA anticoagulant), urine

Reference range: 

 Plasma and Serum: 1.00mg/L~3.00mg/L

Urine≤0.30mg/L

Storage and Stability:

Detection Buffer is stable for 12 months at 2°~8°C.

Sealed Test Device is stable for 12 months at 2°C~30°C. 

Introduction

β2-microglobulin (β2-MG) is a small molecular globulin produced by lymphocytes, platelets and polymorphonuclear leukocytes with a molecular weight of 11,800.
It is the β chain (light chain) of human lymphocyte antigen (HLA) on the cell surface. . It is widely found at very low levels in plasma, urine, cerebrospinal fluid, saliva.
In healthy people, the synthesis rate and release amount of β2-MG from the cell membrane are constant. β2-MG can be filtered freely from the glomeruli, and 99.9% of filtered β2-MG are reabsorbed and degraded by proximal renal tubules.
In conditions where the function of glomerulus or renal tubule is altered , the level of β2-MG in blood or urine will also change.
The level of β2-MG in serum can reflect the filtration function of glomerulus and thus the level of β2-MG in urine is a marker for the diagnosis of proximal renal tubules damage.

Consensus & Guidelines

KDIGO Clinical Practice Guideline on Glomerular Diseases(2020)》

The measurement of fractional urinary excretion of IgG, β-2 microglobulin, retinol binding protein, or α-1 macroglobulin may have clinical and prognostic utility in specific diseases, such as Membranous nephropathy and Focal segmental glomerulosclerosis.

KDIGO Clinical Practice Guideline for Acute Kidney Injury(2012)》

First, regardless of whether acute kidney injury (AKI) developed, all subjects had early evidence of tubular dysfunction and stress, shown by early β2-microglobulinuria. 

 

Clinical Applications

Assessment of glomerular filtration function

The main reason for the increase of β2-MG in blood and the normal β2-MG in urine may be the decrease of glomerular filtration function, which is commonly in acute and chronic nephritis and renal failure, etc.

Assessment of renal tubular reabsorption

The level of β2-MG in blood is normal but increases in urine is mainly due to the obviously impaired renal tubular reabsorption, which is found in congenital proximal renal tubules function defect, Fanconi syndrome, chronic cadmium poisoning, Wilson's disease, renal transplant rejection, etc.

 Other diseases

Elevated levels of β2-MG may also be seen in cancers involving white blood cells, but it is particularly meaningful in people newly diagnosed with multiple myeloma. 


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